Consenso de hemofilia en México

Hemophilia is a hemorrhagic disorder with sex-linked inherited pattern, characterized by an inability to amplify coagulation due deficiency in factor VIII (hemophilia A or classic) IX B). Sequencing of the genes involved hemophilia has provided description and record main mutations, as well correlation various degrees severity. Hemorrhagic manifestations are related levels circulating factor, mainly affecting musculoskeletal system specifically large joints (knees, ankles, elbows). This document review consensus genetic aspects hemophilia, from inheritance pattern concept women carriers, physiopathology classification disorder, basic confirmation studies when suspected, treatment regimens based on infusion deficient innovative factor-free therapies recommendations for management complications associated (development inhibitors and/or transfusion-transmitted infections), secondary articular events (hemophilic arthropathy). Finally, relevant reviews clinical pathology acquired FVIII neutralized antibodies named hemophilia.